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Top medical body ICMR issues advisory for use of Feluda Covid test

Top medical body ICMR issues advisory for use of Feluda Covid test

Top medical body ICMR issues advisory for use of Feluda Covid test
October 23
15:12 2020

Feluda uses CRISPR gene-editing technology to identify and target the genetic material of Sars-CoV2, the virus that causes Covid-19

The Indian Council of Medical Research (ICMR) has issued an advisory for the use of FELUDA paper strip test, the country’s first indigenous developed test for coronavirus disease (Covid-19) based on the genetic editing tool CRISPR/Cas-9, which is likely to hit the market within a month.

As indicated by the ICMR warning, no further reverse transcription-polymerase chain reaction (RT-PCR) based affirmation is needed for tests that are affirmed as positives or negatives by it; example assortment and move of test for the test must be performed utilizing fitting individual defensive gear; and testing ought to be completed under proper biosafety (BSL2 level) precautionary measures, observing the standard RT-PCR rules set somewhere around the clinical body.

Feluda utilizes CRISPR quality altering technology to recognize and focus on the genetic material of Sars-CoV2, the infection that causes Covid-19. CRISPR, which is short for Clustered Regularly Interspaced Short Palindromic Repeats, is a quality altering technology that can be utilized to recognize a particular scrap of DNA from a grouping.

The paper strip test has been created by the Council for Scientific and Industrial Research-Institute of Genomics and Integrative Biology (CSIR-IGIB) and has been affirmed by the Drug Controller General of India for a business dispatch.

The warning likewise permits existing ICMR-affirmed government and private research centers for SARS-CoV-2 RT-PCR based testing to be utilized for this new test. No further endorsement would be needed from ICMR for beginning the test in existing research centers; nonetheless, new labs needing to begin the test should apply for ICMR endorsement.

“Any remedy for RT-PCR, CRISPR, TRUENAT, CBNAAT might be viewed as same. All testing information ought to be basically gone into the ICMR COVID-19 web-based interface consistently. Other announcing systems to the state and IDSP ought to likewise be guaranteed according to the set down conventions of COVID-19 case detailing,” says the warning from the top clinical body.

The unit has just been approved by the Department of Atomic Energy’s National Center for Biological Sciences, Bengaluru.

The test is named after an anecdotal investigator made by the late Satyajit Ray, despite the fact that it is likewise an abbreviation for FNCAS9 Editor-Linked Uniform Detection Assay. It has been created by senior researchers Dr. Debojyoti Chakraborty and Dr. Souvik Maiti at CSIR-IGIB.

In light of tests in more than 2,000 patients during the preliminaries at IGIB and on testing in private labs, the test demonstrated 96% affectability and 98% explicitness. This analyzes well to ICMR’s present acknowledgment models of RT-PCR Kit of in any event 95% affectability and at any rate 99% explicitness. Affectability is the capacity of a test to accurately distinguish those with the ailment (genuine positive rate), while test particularity is the capacity of the test to effectively recognize those without the ailment (genuine negative rate).

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